Postmortem examination revealed bilateral persistent fetal glomeruli, tubular dysplasia, and rare tubular necrosis. After initiating peritoneal dialysis, azotemia improved but the patient acutely declined after an episode of regurgitation and ultimately cardiopulmonary arrest. Due to the development of unresponsive oliguric renal failure, puppy's level of care intensified and peritoneal dialysis was initiated and continued over a 12-day course. The puppy was treated with medical management involving fluid therapy, antibiotics, and supportive care. An 8-week-old male intact CKCS was presented to a University Teaching Hospital for the evaluation of vomiting and lab work revealed azotemia. 2019 doi:10.1007/s00222-3.This report describes a case of congenital bilateral renal dysplasia in a Cavalier King Charles Spaniel (CKCS) puppy, which has not been previously reported in the breed. ![]() Diagnosis and management of Paget's disease of bone in adults: A clinical guideline. Current Opinion in Endocrinology, Diabetes and Obesity. Paget's disease of bone: Updates for clinicians. Clinical manifestations and diagnosis of Paget disease of bone. Bone cancer occurs in up to 1% of people with Paget's disease of bone. Sometimes, this increased workload can lead to heart failure. In severe cases, your heart may have to work harder to pump blood to the affected areas of your body. ![]() When Paget's disease of bone occurs in an area where nerves pass through the bone, such as the spine and skull, the overgrowth of bone can compress and damage the nerve, causing pain, weakness or tingling in an arm or leg or hearing loss. Misshapen bones can increase the amount of stress on nearby joints, which can cause osteoarthritis. Leg bones can bow, which can affect your ability to walk. Affected bones break more easily, and extra blood vessels in these deformed bones cause them to bleed more during repair surgeries. The disease can be managed effectively in nearly all people. In most cases, Paget's disease of bone progresses slowly. If you have a relative who has Paget's disease of bone, you're more likely to develop the condition. Paget's disease of bone is more common in England, Scotland, central Europe and Greece - as well as countries settled by European immigrants. Men are more commonly affected than are women. People older than 50 are most likely to develop the disease. Risk factorsįactors that can increase your risk of Paget's disease of bone include: Some scientists believe Paget's disease of bone is related to a viral infection in your bone cells, but this theory is controversial. Several genes appear to be linked to getting the disease. Scientists suspect a combination of environmental and genetic factors contribute to the disease. The cause of Paget's disease of bone is unknown. Request an Appointment at Mayo Clinic Causes
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